Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease
نویسندگان
چکیده
منابع مشابه
The Vascular Endothelium in Diabetes
Key Points • The endothelium is a key participant in the homeostasis of the vessel wall. • Nitric oxide (NO) plays a key role in regulating healthy vascular function. • Reduced local NO bioavailability is a characteristic hallmark of vascular endothelial dysfunction. • Endothelial dysfunction is chiefly driven by oxidative stress and inflammation. • A number of techniques for assessing endothel...
متن کاملThe vascular endothelium as a target of cadmium toxicity.
Cadmium (Cd) is an important industrial and environmental pollutant that can produce a wide variety of adverse effects in humans and animals. A growing volume of evidence indicates that the vascular endothelium may be one of the primary targets of Cd toxicity in vivo. Studies over the past 20 years have shown that Cd, at relatively low, sublethal concentrations, can target vascular endothelial ...
متن کاملClaudin-5 as a novel estrogen target in vascular endothelium.
OBJECTIVE Estrogens have multiple effects on vascular physiology and function. In the present study, we look for direct estrogen target genes within junctional proteins. METHODS AND RESULTS We use murine endothelial cell lines of brain and heart origin, which express both subtypes of estrogen receptor, ERalpha and ERbeta. Treatment of these cells with 17beta-estradiol (E2) led to an increase ...
متن کاملEndothelium-Dependent Attenuating Effect of Trigonella foenum-graecum on the Contractile Vascular Reactivity of Diabetic Rats
The present study was undertaken to determine whether two-month treatment of streptozotocin (STZ)-diabetic rats with aqueous leaf extract of Trigonella foenum-graecum (TFG 200 mg/kg i.p.) could improve thoracic aortic responsiveness and to evaluate its endothelium dependency. For this purpose, vascular responses to KCl and noradrenaline (NA) were measured. Diabetic state significantly increased...
متن کاملThe Endothelium as a Target in Pediatric OSA
Pediatric sleep disordered breathing has emerged in the last few decades as a highly prevalent condition by virtue of its major morbidities encompassing the central nervous, cardiovascular, and metabolic systems. In this context, improved understanding of the pathophysiological mechanisms underlying the cellular and organ injury and repair mechanisms, and the variance of the phenotype at any le...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Journal of Physiology and Pharmacology
سال: 2020
ISSN: 0008-4212,1205-7541
DOI: 10.1139/cjpp-2019-0677